The 5th Brain Tumors: From Biology to Therapy Conference

JUNE 22-24, 2022 the Nencki Institute, Warsaw, Pasteur 3 str.




WEDNESDAY, June 22, 2022

11:00–13:00 Registration and welcome coffee
13:00–14:00 Keynote lecture:

John de Groot, MD Anderson Cancer Center, USA

The future of immunotherapy for glioma

14:00–17:20 Brain tumor pathobiology
(chairs: Dolores Hambardzumyan, Bozena Kaminska)
14:00–14:35 Constantinos G. Hadjipanayis, Icahn School of Medicine at Mount Sinai, USA

Fluorescence-guided surgery and photodynamic therapy of brain tumors: a new combination

14:35–15:10 Martin van den Bent, Erasmus MC Cancer Institute, Rotterdam, the Netherlands

The landscape of clinical trial in glioma: recently completed and ongoing projects

15:10–15:40 Coffee break
15:40–16:15 Oren Becher, Mount Sinai Icahn School of Medicine, USA

Cellular heterogeneity in diffuse midline gliomas

16:15–16.50 Jacek Majewski, McGill University, CanadaEpigenomic landscapes of H3K27M mutant gliomas
16.50-17.20 Oral presentations (3×10 min)
17:20–18:50 Poster session part I
19:00–21:00 Welcome reception


THURSDAY, June 23, 2022

09:00–12:25   Glioma microenvironment, immunology and immunotherapy I
(chairs: Christel Herold-Mende, Aleksandra Ellert-Miklaszewska)
09:00–9:35 Bozena Kaminska, Nencki Institute, Warsaw, Poland

Immune microenvironment of glioma at single cell resolution

09:35–10:10 Dolores Hambardzumyan (Icahn School of Medicine, Mount Sinai, USA)

Glioblastoma subtype-specific heterogeneity of the immune microenvironment

10:10–10:40 Coffee break
10:40–11:15 Katrin Lamszus (Universitätsklinikum Hamburg-Eppendorf; Hamburg, Germany)Cancer immunoediting in malignant glioma – interactions between immune cells and tumor cells
11:15–11:50 Dieter Henrik Heiland, University of Freiburg, Germany

Spatiotemporal dynamics in the structural immunity of the glioblastoma microenvironment

11:50–12.25 Christel Herold-Mende, University of Heidelberg, Germany

Determinants of immune cell infiltration and immune responses in brain tumors

12:25–13:25 Lunch break
13:25–18:00 Brain tumor microenvironment, immunology and immunotherapy II
(chairs: Dinorah Friedman-Morvinski, Wiesława Grajkowska)
13:25–14:00 Alessandro Michelucci, Neuro-Immunology Group, Department of Oncology, Luxembourg Institute of Health, LuxembourgRevealing and harnessing tumor-associated microglia/macrophage heterogeneity in glioblastoma
14:00–14:35 Waldemar Debinski, Wake Forest School of Medicine, USA

Novel targeted drug candidates for GBM treatment

14:35–15:10 Dinorah Friedmann-Morvinski, Tel Aviv University, Israel

Boosting CAR T cell efficacy by modulation of the microenvironment in brain tumors

15:10–15:35 Coffee break
15:35–16:10 Houtan Noushmehr, Henry Ford Cancer Institute, USA

Advances in epigenomic classification and liquid biopsy in glioma

16:10–16:45 Neta Erez, Tel Aviv University, Israel

Systemic instigation of neuroinflammation facilitates brain metastasis

16:45–17:20 Hai-kun Liu, German Cancer Research Center (DKFZ), GermanyMetabolic plasticity and cancer stem cell dormancy in glioblastoma
17:20-17.50 Oral presentations (3×10 min)
17.50–19:40 Poster session part II
20:00-23:00 Gala dinner (by invitation)


FRIDAY, June 24, 2022

09:00–15:60 Brain tumor pathobiology, diagnostics & therapy
(chairs: Tika Benveniste, Sergiusz Nawrocki)
09:00–9:35 Itay Tirosh, Weizmann Institute of Science, Israel

Dissecting intra-tumor and inter-tumor heterogeneity in glioma

09:35–10:10 Rolf Bjerkvig, University of Bergen, Norway

Glioma cell invasion: growth patterns and mechanistic insight

10:10–10:40 Coffee break
10:40–11:15 Guido Reifenberger, University of Dusseldorf, Germany


11:15–11:50 Maciej S. Lesniak, Northwestern University Feinberg School of Medicine, USA

Targeting HER2+ Breast Cancer Metastases in the Brain

11:50–12:25 Maria G. Castro, University of Michigan Medical School, USA

Epigenetic reprogramming of the tumor immune microenvironment in mutant IDH1 gliomas mediated myeloid cell populations and reverses immunosuppression

12:25–13:25 Lunch break
13:25–14:00 Maciej Wiznerowicz, International Institute for Molecular Oncology, PolandCancer Stemness as Hallmark of Oncogenic De-differentiation
14:00–14:35 Petra Hamerlik, Astrazeneca, UKFunctional interplay between aberrant DNA repair and cellular hierarchies in glioblastoma
14:35–15:10 Agnieszka Bronisz, Mossakowski Medical Institute, Poland

Targeting hypoxia response for oncolytic virus immunotherapy

15:10-15:45 Waldemar Priebe, MD Anderson Cancer Center, University of Texas,
Houston, USA
Drug discovery in academia: focus on CNS malignancies
15:45-16:20 Glenn Lesser, Wake Forest School of Medicine, USATBA
16:20–16.30 Closing remarks
16.30–19:00 Guided tour: Warsaw sightseeing